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cdd-111  (Confluence Life Sciences)

 
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    Confluence Life Sciences cdd-111
    Cdd 111, supplied by Confluence Life Sciences, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/cdd-111/cdd+111/bio_rxiv__664755-40-23-36
    Average 90 stars, based on 1 article reviews
    cdd-111 - by Bioz Stars, 2026-09
    90/100 stars

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    Related Articles

    other:

    Article Title: p38MAPK plays a crucial role in stromal mediated tumorigenesis
    Article Snippet: Fibroblasts were treated with actinomycin D (10 μg/mL, Sigma, St. Louis, MO) for 24 hours, SB203580 (10 μM, Millipore, Billerica, MA) for 48 hours, or CDD-111 (also referred to as SP-006, 1 μM, Confluence Life Sciences, St. Louis, MO) for 48 hours unless indicated otherwise.

    Article Title: The p38MAPK-MK2-HSP27 Pathway Regulates the mRNA Stability of the Senescence-Associated Secretory Phenotype
    Article Snippet: Fibroblasts were treated with actinomycin D (10 μg/mL, Sigma Aldrich, St. Louis, MO) for 24 hours, and SB203580 (10 μM, Millipore, Billerica, MA), CDD-111 (also referred to as SD0006, 1 μM), or CDD-450 (1μM, both from Confluence Life Sciences, St. Louis, MO) every 24h unless indicated otherwise.



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    (A) Western blot analysis demonstrating that SB203580 treatment inhibits <t>p38MAPK</t> activity. As expected, SB203580 treatment significantly impacts phosphorylation of p38MAPK’s direct downstream target, Hsp27. Total Hsp27 was used as loading control.
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    Image Search Results


    (A) Western blot analysis demonstrating that SB203580 treatment inhibits p38MAPK activity. As expected, SB203580 treatment significantly impacts phosphorylation of p38MAPK’s direct downstream target, Hsp27. Total Hsp27 was used as loading control.

    Journal: Cancer discovery

    Article Title: p38MAPK plays a crucial role in stromal mediated tumorigenesis

    doi: 10.1158/2159-8290.CD-13-0743

    Figure Lengend Snippet: (A) Western blot analysis demonstrating that SB203580 treatment inhibits p38MAPK activity. As expected, SB203580 treatment significantly impacts phosphorylation of p38MAPK’s direct downstream target, Hsp27. Total Hsp27 was used as loading control.

    Article Snippet: Oral dosage of p38MAPK inhibitor The p38MAPK small molecule inhibitor CDD-111 (Confluence Life Sciences, Inc, St. Louis, MO) was compounded at 516 ppm with Purina Rodent Chow #5001 (St. Louis, MO) to generate a daily exposure of 80 mg/kg/day.

    Techniques: Western Blot, Activity Assay

    (A) RNA-seq analysis was performed on young fibroblasts, senescent fibroblasts, and senescent fibroblasts treated with SB203580. RNA-seq results were analyzed to determine the number of factors upregulated in response to senescence (SASP factors) and the number of p38MAPK-dependent factors. These results were also analyzed for overlap with the expression profiles of breast cancer (BC)-associated stroma.

    Journal: Cancer discovery

    Article Title: p38MAPK plays a crucial role in stromal mediated tumorigenesis

    doi: 10.1158/2159-8290.CD-13-0743

    Figure Lengend Snippet: (A) RNA-seq analysis was performed on young fibroblasts, senescent fibroblasts, and senescent fibroblasts treated with SB203580. RNA-seq results were analyzed to determine the number of factors upregulated in response to senescence (SASP factors) and the number of p38MAPK-dependent factors. These results were also analyzed for overlap with the expression profiles of breast cancer (BC)-associated stroma.

    Article Snippet: Oral dosage of p38MAPK inhibitor The p38MAPK small molecule inhibitor CDD-111 (Confluence Life Sciences, Inc, St. Louis, MO) was compounded at 516 ppm with Purina Rodent Chow #5001 (St. Louis, MO) to generate a daily exposure of 80 mg/kg/day.

    Techniques: RNA Sequencing Assay, Expressing

    (A) Western blot analysis demonstrating that SB203580 treatment inhibits p38MAPK activity. As expected, SB203580 treatment significantly impacts phosphorylation of p38MAPK’s direct downstream target, Hsp27. Total Hsp27 was used as loading control.

    Journal: Cancer discovery

    Article Title: p38MAPK plays a crucial role in stromal mediated tumorigenesis

    doi: 10.1158/2159-8290.CD-13-0743

    Figure Lengend Snippet: (A) Western blot analysis demonstrating that SB203580 treatment inhibits p38MAPK activity. As expected, SB203580 treatment significantly impacts phosphorylation of p38MAPK’s direct downstream target, Hsp27. Total Hsp27 was used as loading control.

    Article Snippet: We obtained a p38MAPK inhibitor (CDD-111, also referred to as SD-0006 ( 38 ), Confluence Life Sciences) and compounded it into mouse chow.

    Techniques: Western Blot, Activity Assay, Phospho-proteomics, Control

    (A) RNA-seq analysis was performed on young fibroblasts, senescent fibroblasts, and senescent fibroblasts treated with SB203580. RNA-seq results were analyzed to determine the number of factors upregulated in response to senescence (SASP factors) and the number of p38MAPK-dependent factors. These results were also analyzed for overlap with the expression profiles of breast cancer (BC)-associated stroma.

    Journal: Cancer discovery

    Article Title: p38MAPK plays a crucial role in stromal mediated tumorigenesis

    doi: 10.1158/2159-8290.CD-13-0743

    Figure Lengend Snippet: (A) RNA-seq analysis was performed on young fibroblasts, senescent fibroblasts, and senescent fibroblasts treated with SB203580. RNA-seq results were analyzed to determine the number of factors upregulated in response to senescence (SASP factors) and the number of p38MAPK-dependent factors. These results were also analyzed for overlap with the expression profiles of breast cancer (BC)-associated stroma.

    Article Snippet: We obtained a p38MAPK inhibitor (CDD-111, also referred to as SD-0006 ( 38 ), Confluence Life Sciences) and compounded it into mouse chow.

    Techniques: RNA Sequencing, Expressing

    (A) Western blot analysis demonstrating that SB203580 treatment inhibits p38MAPK activity. As expected, SB203580 treatment significantly impacts phosphorylation of p38MAPK’s direct downstream target, Hsp27. Total Hsp27 was used as loading control.

    Journal: Cancer discovery

    Article Title: p38MAPK plays a crucial role in stromal mediated tumorigenesis

    doi: 10.1158/2159-8290.CD-13-0743

    Figure Lengend Snippet: (A) Western blot analysis demonstrating that SB203580 treatment inhibits p38MAPK activity. As expected, SB203580 treatment significantly impacts phosphorylation of p38MAPK’s direct downstream target, Hsp27. Total Hsp27 was used as loading control.

    Article Snippet: Oral dosage of p38MAPK inhibitor The p38MAPK small molecule inhibitor CDD-111 (Confluence Life Sciences, Inc, St. Louis, MO) was compounded at 516 ppm with Purina Rodent Chow #5001 (St. Louis, MO) to generate a daily exposure of 80 mg/kg/day.

    Techniques: Western Blot, Activity Assay, Phospho-proteomics, Control

    (A) RNA-seq analysis was performed on young fibroblasts, senescent fibroblasts, and senescent fibroblasts treated with SB203580. RNA-seq results were analyzed to determine the number of factors upregulated in response to senescence (SASP factors) and the number of p38MAPK-dependent factors. These results were also analyzed for overlap with the expression profiles of breast cancer (BC)-associated stroma.

    Journal: Cancer discovery

    Article Title: p38MAPK plays a crucial role in stromal mediated tumorigenesis

    doi: 10.1158/2159-8290.CD-13-0743

    Figure Lengend Snippet: (A) RNA-seq analysis was performed on young fibroblasts, senescent fibroblasts, and senescent fibroblasts treated with SB203580. RNA-seq results were analyzed to determine the number of factors upregulated in response to senescence (SASP factors) and the number of p38MAPK-dependent factors. These results were also analyzed for overlap with the expression profiles of breast cancer (BC)-associated stroma.

    Article Snippet: Oral dosage of p38MAPK inhibitor The p38MAPK small molecule inhibitor CDD-111 (Confluence Life Sciences, Inc, St. Louis, MO) was compounded at 516 ppm with Purina Rodent Chow #5001 (St. Louis, MO) to generate a daily exposure of 80 mg/kg/day.

    Techniques: RNA Sequencing, Expressing